Porous Peptide Frameworks

We develop synthetic peptides that self-assemble into crystalline materials containing pores and channels. These pores are decorated with many mutable residues, making them mimics of protein active sites. We are exploring them as protein-like heterogenous catalysts and molecular binders.

Metalloenzyme Excision

To better understand how metalloproteins work, we extract motifs from proteins in the form of stabilized peptides. This project leverages synthetic strategies to preserve the secondary and tertiary structure those excised regions.

In crystallo Bioinorganic Chemistry

This project replicates metalloenzyme active sites within crystalline porous frameworks. The goal is to better understand the structures of reactive intermediates by generating them within the crystal matrix. Furthermore, these are explored as potential catalysts for various reactions.